Mecobalamin, Alpha Lipoic Acid and B vitamins is a unique combination which helps in diabetic neuropathy and used to lower homocysteine levels and other vitamin deficiencies.
Neuropathy is damage to nerves, and diabetic neuropathy is damage to nerves that occurs as a result of diabetes. Diabetes is thought to damage nerves as a result of prolonged elevated levels of blood glucose. Diabetic neuropathy can affect different parts of the body, and symptoms can range from mild to severe. Diabetic neuropathy is the most common complication of diabetes. Nerve damage or diabetic neuropathy resulting from chronically high blood glucose can be one of the most frustrating and debilitating complications of diabetes because of the pain, discomfort and disability it can cause, and because available treatments are not uniformly successful.
The mechanisms involved in the development of diabetic neuropathy include changes in the blood vessels that supply the peripheral nerves; metabolic disorders, such as the enhanced activation of the polyol pathway; myo-inositol depletion; and increased non-enzymatic glycation.
Methylcobalamin is an essential nutrient for neurons and is known as an energy vitamin and supports our immune system. This is also essential for critical functions of our body like formation of red blood cells etc. retards ageing of the brain, boosts nerve myelination, regularizes sleep patterns, and decreases serum homocysteine levels.
Alpha-lipoic acid (ALA) is a potent antioxidant which is used to reduce the free radicals, produced in diabetic persons and protects the neurons from oxidative stress.
Pyridoxine enhances myelin sheath formation, and folic acid regulates amino acid metabolism.
Thiamine reduces pain and improves nerve conduction velocity. Thiamine modulates nerve impulse transmission, hence its usefulness in neuropathy and nerve pain syndromes. It is an integral component of synaptic membranes in brain and neural tissues.
Folic acid with mecobalamin plays vital roles in numerous metabolic processes in the human body, such as nervous system development and functioning.
The ratio of Methylcobalamin, ALA, and B vitamins helps in bringing down the plasma level of homocysteine, the major risk factor for Atherosclerosis. Alpha Lipoic Acid prevents plaque formation in the arteries by preventing LDL oxidation. Thus this combination also reduces the major risk factors for Atherosclerosis.
Functions:
This combination improves the condition by performing the following functions on the body:
⇒ Increasing the production of red blood cells by bone marrow
⇒ Modifying the electrical activity thus relaxing and slowing overactive heart muscles
⇒ Producing and maturing the red blood cells
⇒ Relaxing the nerve signals to the brain

Several vitamins and supplements have been shown to play some positive role in helping Diabetic Peripheral Neuropathy (DPN). These nutrients and supplements have shown some supportive role toward:
⇒ Healthy blood sugar levels - the foundation of nerve health
⇒ Healthy nerves to alleviate direct nerve damage and its symptoms
⇒ Healthy blood circulation to the nerves to indirectly support relief of diabetic neuropathy

Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.
Methyl B12 is more effective than traditional forms of B12 for treating pernicious anemia (B12 deficiency) as there is no need for conversion by the body and is better retained by the liver and other tissues. It is the active form of vitamin B12 found in better DPN supplements. Vitamin B12's main functions are in the formation of red blood cells and DNA that make up your genes. It is involved in having a healthy nervous system, and plays a vital role in the metabolism of healthy fats essential for maintenance of the important covering that surrounds your nerves known as the myelin sheath. In the diabetic, B12 is typically used to assist in the management of diabetic neuropathy, and for general nerve health. The main property of vitamin B12 that has been studied for DPN is its role in managing homocysteine levels - Elevated levels of homocysteine in the blood have been associated with poor circulation, and it is believed that the decreased circulation in the tiny blood vessels that feed the nerves are part of the problem in people with DPN.

Alpha lipoic acid (ALA) is found naturally in the body. It has many interesting properties including being a powerful antioxidant and anti-inflammatory. High blood sugar levels are associated with excess generation of highly reactive free radicals and oxidative stress. ALA promotes antioxidant effects in the body mostly by directly eliminating harmful free radicals. It also appears to play a role in blood sugar levels as well as having an apparent beneficial effect on managing the symptoms of diabetic neuropathy. Having antioxidant properties it has the ability to chelate metals and to scavenge free radicals. Lipoic acid is easily absorbed and transported across cell membranes; thus, free radical protection occurs both inside and outside of cells. It is water- and fat-soluble, which makes it more effective against a broader range of free radicals than vitamin C (water-soluble) and vitamin E (fat-soluble) alone. Lipoic acid administration also increases intracellular levels of glutathione, an important antioxidant.

Vitamin B1 is an essential nutrient, which helps to produce energy from food, contributes to metabolism of glucose and enables proper functioning of the nerves, brain, muscles and heart. Thiamine is a water-soluble vitamin that participates in carbohydrate metabolism. Deficiency of thiamine causes beriberi, characterized by painful peripheral neuropathy and cardiomyopathy. It acts as an activating molecule (cofactor, coenzyme) for the enzymes involved in the breakdown of carbohydrates and proteins and thus enables the release of energy from them and especially important for proper functioning of the nerves, brain, muscles and heart. Thiamine is also involved in the production of gastric acid, neurotransmitters GABA and acetylcholine, maintaining the myelin nerve sheaths and in breakdown of alcohol. Thiamine deficiency may also be involved in the etiology of diabetic neuropathy by preventing the glycation of nerve fibers as well as apoptosis of endothelial cells. Thiamine and pyridoxine were helpful in improving the pain experienced in diabetic peripheral neuropathy as well as improving signs of neuropathy.

It is also called vitamin B9, and also essential to many of body's functions. The human body needs folic acid to make, repair, and regulate DNA, to develop red blood cells, to support good nervous system function, and to act as a cofactor in many of the biological reactions that keep you healthy. It participates in the breakdown of fat in fat cells and may have some role in the prevention of obesity and type-2 diabetes. Many people know that diabetes is a disease of blood sugar control, but many do not know that it is also a disease of fat storage. Any dietary nutrient that plays a supportive role in proper fat metabolism needs to be a regular part of the diabetes and pre-diabetes diet.
Folic acid, as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase. These folic acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate. Using vitamin B12 as a cofactor, folic acid can normalize high homocysteine levels by remethylation of homocysteine to methionine via methionine synthetase.

Vitamin B6, or pyridoxine, is a vitamin that has many important functions in the body. One of its roles is to help the nervous system work well. The nervous system is what is affected by peripheral neuropathy (PN). Some cases of PN have been linked to vitamin B6 deficiency.
It is involved in many areas of your metabolism, from the formation of hemoglobin that carries oxygen in your blood, to the working of your genes, to the release of stored-up glucose in your muscles, and many other important actions including the formation of the biologic chemicals that nerves use to "talk to one another." And like vitamin B12 it is also involved in the formation of the covering for nerves - the myelin sheath, this is one way in which it is directly supports nerve health. Vitamin B6 plays an important role in the body. It is needed to maintain the health of nerves, skin, and red blood cells. Pyridoxine has been used to cure a certain nerve disorder (peripheral neuropathy) caused by certain medications (such as isoniazid).

Indications & Usage:

⇒ Used for diabetic neuropathy and peripheral neuropathy
⇒ Helps the body make healthy new cells
⇒ Protects cells from oxidative damage
⇒ Protective effects on brain and nerve tissues
⇒ Potentiates glucose uptake
⇒ Effectively controls nerve impairment
⇒ Effective in burning sensations and Tingling effects
⇒ Effective in numerous neurodegenerative disorders
⇒ Improves nerve function
⇒ Useful in anemia due to folic acid deficiency

Contraindications:

Hypersensitivity to any ingredient of the composition. Anaphylactic reaction and other sensitivity reactions.

Side Effects:

The product is possible safe for most adults. There is no disadvantage associated with the product if taken under the recommended usage.
However, some are: headache, nausea, vomiting, and upset stomach.

Special Precautions:

For Pregnancy and Breast-Feeding mothers: Not recommended

Storage:

Store in a cool, dry & dark place. Protected from direct sunlight.